Hyaluronidase – The “Magic Eraser” for Hyaluronic Acid (Juvederm, Restylane) Dermal Fillers

Hyaluronic Acid dermal fillers are the most popular fillers used worldwide.  In the United States, the commonly used HA fillers are:

  1. Juvederm Ultra and Ultra Plus
  2. Voluma
  3. Restylane
  4. Perlane
  5. Belotero

The beauty of HA fillers is that they are very well tolerated because hyaluronic acid is a component of skin, so it is a naturally occurring substance.  It’s a soft product, and will last anywhere from 4 months, to up to 2 years, depending on the brand used, and the location it is placed.

Another key attribute to the HA fillers popularity is that it can be completely dissolved with an enzyme called hyaluronidase.  It is manufactured from either bovine (cow) or ovine (sheep), so there is a remote possibility of having an allergic reaction to the commercially available products (Vitrase, Hydase, and Amphadase).  There seems to be a crossover with people that are allergic to bees for these animal derived products.  (Hylenex is a recombinant form of hyaluronidase that is the human form that is rarely used due to its expense.)

Hyaluronidase is useful for dissolving HA filler in the following instances:

  1. The filler was over done/”over filled” and it is not aesthetically pleasing
  2. There is prolonged swelling, particularly around the eye and most often with Juvederm
  3. An infection has occurred in the area of prior filler
  4. The filler is lumpy or has nodules and doesn’t respond to massage and time (especially lips)
  5. Rare possible allergic reaction to the HA filler
  6. When there is vascular compromise secondary to the HA filler injection which can be caused by external compression on a vessel or intraluminal (within the vessel) injection

My experience with hyaluronidase has been mostly with patients that have had Juvederm injected in the tear trough area from another facility.  I strongly recommend that Juvederm not be injected in this area because of the risk of prolonged edema.  The reason this happens more with Juvederm is speculated to be due to its ability to attract more water, and because it spreads more diffusely than the other fillers.

When injecting hyaluronidase, it is mixed with lidocaine by the physician, so it is a fairly comfortable procedure.  There are a couple limiting factors with the injection.  It is not as precise as the filler injection, so it can remove some of the filler that you wanted to stay along with the unwanted filler.  Also, dosing/how much to use, is not an exact science.  It may take more than one treatment to dissolve the HA filler.  The results can occur within minutes, but usually take about a day to fully appreciate.  Also, Juvederm tends to be the hardest to dissolve, and it thought that this is related to the way it is cross linked (manufacturing process).  I imagine that Voluma would be similar to Juvederm or maybe even harder to dissolve, but I don’t have any experience with it yet.

The bottom line is that you don’t have to live with HA filler that you are not happy with.  You can easily reverse lips that are lumpy or too big, swelling around the eye from filler, or dissolve an over correction or asymmetry with hyaluronidase.  An injection with hyaluronidase can get you back to where you used to be in about 24 hours.  Also, it’s nice to have a little piece of mind when getting injected with an HA filler that the process can be completely reversed with a small procedure.

Dr. Steve Weiner is a Facial Plastic Surgeon who “laid down his scalpel” in 2005 and concentrates solely on non invasive and minimally invasive cosmetic procedures at The Aesthetic Clinique.   His website is http://www.theclinique.net .  Call for a consultation:  850.622.1214

Blog: http://stevenfweinermd.wordpress.com/

YouTube: http://www.youtube.com/user/StevenFWeinerFacial

About these ads

6 Comments

  1. julie

    Hi please could you help I had uma junesse put in one side of my face for the lines. It spread up my face towards my eyesocket I have just recently felt tiny beads top of my cheek bone under eye socket and one larger lump on my eye. Where can I get these dissolved please.

    • I’m not familiar with this but after researching, it is a hyaluronic acid and should respond to hyaluronidase.

    • This is a hyaluronic acid and should be dissolved with hyaluronidase.

  2. nelly

    Hy i have teosyal redisinty 2 for eyes on 25 january and than to touch up on 2 april and than begin the problems with swelling etc. so i have hylase on 11 july 2014 one treatment. it goes raplidly down. my question is how long it takes the naturel hyluronic acid comes back and the skin rehabes. it is 2 months ago, it looks a little bit better but not so like before the treatment with the filler.
    I’m 27 years old and i’m from switzerland please can you answering me. sorry for my bad english.

    • I should go back to where it was before you had filler very quickly. If it’s not, go see your doctor again.

  3. Quite nice and productive article shared on Dermal Fillers, must be compulsorily read by all prospective skin treatment aspirants

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Follow

Get every new post delivered to your Inbox.

Join 15,209 other followers

%d bloggers like this: